Proteo Incorporation (Pink Sheets: PTEO) zoomed to the top of the leaderboard among microcap gainers Wednesday, tacking on 357.1% in price to 96 cents, albeit on small volume of only 1,000 shares (still 20 times its daily volume). The company researches, develops and markets compounds for biological and medical research as well as for use as pharmaceuticals.

Optimized Transportation Management Inc. (Pink Sheets: OPTZ) dealt in 45.6 million shares Wednesday, or triple its daily average, selling at six-100ths of a cent or 50% higher than Tuesday.

Commerce Group Corp. (Pink Sheets: CGCO) withered 55% in price to nine-10ths of a cent Wednesday, on volume of 161,000 shares, more than six times its daily average.